What causes the autoimmune disorders associated with HLA-B27? This group of tests may include an RF (rheumatoid factor) with an ESR (erythrocyte sedimentation rate) and a CRP (C-Reactive protein). Other disorders that have an association with the presence of HLA-B27 include juvenile rheumatoid arthritis (JRA), reactive arthritis (including Reiter syndrome), and isolated acute anterior uveitis. Several thousand different types are known. In most cases, your blood sample will be sent to a reference laboratory. These may be displayed in such a way that the immune system cannot distinguish them from protein fragments from the microorganisms. If a person has a close family member with an HLA-B27 related disease that affects the joints of the spine (AS or other related condition) and is positive for the HLA-B27 antigen, then that person is at an increased risk of developing a similar disease. Tests: ESR; CRP; RF; HLA testing HLA A is one of three major types (HLA A, HLA B, HLA C) of human major histocompatability complex class I cell surface receptors. If a person is positive for HLA-B27 and has symptoms such as chronic pain, inflammation, and/ or consequent damage to the spine and joints (as seen on X-ray, or other imaging), then it supports a diagnosis of ankylosing spondylitis, reactive arthritis, or another autoimmune disorder that is associated with the presence of HLA-B27. One common HLA protein is HLA-B27. A positive HLA-B27 in a person who does not have symptoms or a family history of HLA-B27-associated disease is not clinically significant or helpful. National Ankylosing Spondylitis Society. The HLA gene complex resides on a 3 Mbp stretch within chromosome 6p21. An immune response to these “self-proteins” than occurs after the infection has been cleared and so autoimmune disease develops. Ankylosing spondylitis is characterised by pain. The human leukocyte antigen (HLA) system or complex is a group of related proteins that are encoded by the major histocompatibility complex (MHC) gene complex in humans. Can I be tested for HLA-B27 in my doctor's surgery? If the doctor wants to see you about the result(s), you will be offered an appointment. However, it is helpful as one piece of evidence amongst others like signs, symptoms, and other lab tests to support or rule out the diagnosis of these disorders. The HLA-B27 test is primarily requested to help strengthen or confirm a suspected diagnosis of ankylosing spondylitis (AS), reactive arthritis, juvenile rheumatoid arthritis (JRA), or sometimes anterior uveitis . They enable it to distinguish our own cells and proteins from those of bacteria, viruses and other “invaders” and so enable it to identify these invaders for attack whilst avoiding attacking its own cells. Please consult your doctor or the laboratory that performed the test(s) to obtain the reference range if you do not have the lab report. Over 100 different subtypes of the HLA-B27 gene exist. British Society of Rheumatology The lab report containing your test results should include the relevant reference range for your test(s). Everybody has a number of different types of these proteins on each cell and together they make up an individual’s “Tissue Type”. For these reasons, you will not find reference ranges for the majority of tests described on this web site. Should everyone have an HLA-B27 test done? Some specialist test results may take longer, if samples have to be sent to a reference (specialist) laboratory. Different forms of the HLA antibody are involved in autoimmune diseases. Conditions: Autoimmune Disorders, JRA, Ankylosing Spondylitis, Reactive Arthritis, Elsewhere On The Web These are diseases in which the body attacks its own tissues. If the test is positive, this means that HLA-B27 is present in your blood. Anterior uveitis is associated with recurring inflammation of the structures of one or both eyes. HLA-B27 is also more common in people with spondylitis associated with inflammatory bowel disease and psoriatic arthritis. The most common of these disorders is ankylosing spondylitis (AS). HLA-B27 production is controlled by genes, passed from parents to children. If you are concerned about your test results, you will need to arrange an appointment with your doctor so that all relevant information including age, ethnicity, health history, signs and symptoms, laboratory and other procedures (radiology, endoscopy, etc. An HLA-B27 test may be requested when a person has acute or chronic pain and inflammation in the spine, neck, chest, eyes, and/or joints, and the doctor suspects an autoimmune disorder that is associated with the presence of HLA-B27. Several thousand different types are known. However, this does not completely exclude the possibility that the person has the suspected condition, as a small percentage of people with each disorder will be HLA-B27 negative: Whether or not HLA-B27 is positive is genetically determined.

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