However, various novel experimental and clinical approaches show promise for improving cure rates. The statistics below talk about median survival. Death rates from leukemia are higher among the elderly. In CALGB study 8513, all therapy ended after 29 weeks [18]. Blood 80:2983-2990, 1992. J Clin Oncol 1:462-469, 1983. 18. Fière D, Lepage E, Sebban C, et al: Adult acute lymphoblastic leukemia: A multicentric randomized trial testing bone marrow transplantation as postremission therapy. Mandelli F, Annino L, Vegna ML, et al: GIMEMA ALL 0288: A multicentric study on adult acute lymphoblastic leukemia: Preliminary results. This induction regimen was followed by early and late intensification courses. Radford JE Jr, Burns CP, Jones MP, et al: Adult acute lymphoblastic leukemia: Results of the Iowa HOP-L protocol. The estimate comes from annual data based on the number of people with this cancer in the United States. The poorer prognosis associated with certain karyotypes has dictated that different approaches be taken with these patients, as discussed below. In chronic myelogenous leukemia, this results in the production of the hybrid protein p210, but in Philadelphia-positive ALL, either a p210 or a smaller p190 protein results. N Engl J Med 316:1111-1117, 1987. There is more than one way to describe a person’s likely prognosis (outlook). Blood 73:57-63, 1989. Blood 80:2471-2478, 1992. Tax ID Number: 13-1788491. 32. 23. 22. The International Bone Marrow Transplant Registry performed a retrospective review of the results of BMT vs intensive consolidation chemotherapy in adults with ALL in first remission [30]. The survival rate for people with CLL varies widely according to the stage of the disease (see Stages). Anderson Cancer Center described 52 elderly patients treated with infusional VAD. © 2005-2020 American Society of Clinical Oncology (ASCO). Cancer Information, Answers, and Hope. Such prognostic information may, ultimately, be used to assign risk categories and to individualize post-remission therapy. Sobol RE, Mick R, Royston I, et al: Clinical importance of myeloid antigen expression in adult acute lymphoblastic leukemia. One or more of these mechanisms may be active in any individual patient. The German ALL Group enrolled 368 patients (median age, 25 years) into a multicenter study [9] over a 5-year period from 1978 to 1983. Some period of maintenance chemotherapy has traditionally been givenfor 1 to 3 years, using mercaptopurine (Purinethol) and methotrexate, often with monthly pulses of vincristine and prednisone. Patients then received maintenance therapy until they were in continuous complete remission for 2½ years. Median survival estimates are based on previous outcomes of large numbers of people who had the disease, but they cannot predict what will happen in any particular person’s case. Bloomfield CD, Gold AI, Alimena G, et al: Chromosomal abnormalities identify high-risk and low-risk patients with acute lymphoblastic leukemia. 2. Percent means how many out of 100. Philadelphia chromosome-positive ALL also has proved difficult to treat, although some progress has been made. The early intensification program included 2 months of treatment with cyclophosphamide, intrathecal methotrexate, subcutaneous cytarabine, oral mercaptopurine, intravenous vincristine, and additional asparaginase. Although the true value of CNS prophylaxis in adults is controversial, studies in which adult patients either refused or could not receive CNS prophylaxis have demonstrated a higher rate of CNS relapse than was seen in patients receiving such treatment. While relapse rates were lower among those who received transplants, this advantage was offset by a high rate of transplant-related mortality. [ONCOLOGY 9(5):433-450, 1995]. Indeed, the most predictable clinical outcomes occur when patients are classified according to recurring cytogenetic abnormal- ities.4 The most common of these involves the Philadelphia chromosome [3]. Many types of leukemia exist. See all references for Chronic Myelomonocytic Leukemia.

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